Skin Botox vs. Rejuran in Cheongdam | Ingredients, Treatment Goals and Timing
2026-10-30
Contents
What are the differences between Skin Botox and Rejuran?
When the skin texture becomes rough, pores become prominent, and fine wrinkles start to concern you, you may consider injection treatments to improve your skin condition. At this time, the treatments often compared are Skin Botox and Rejuran.
Both treatments are applied directly to the skin, but there are differences in the ingredients used and their mechanisms of action.
Skin Botox involves injecting small amounts of botulinum toxin into the shallow layers of the skin, primarily used to manage changes on the skin surface such as sebum production, pore appearance, and fine wrinkles.
On the other hand, Rejuran is a treatment that injects PN (Polynucleotide) into the skin to aid in tissue recovery and improve skin condition. It is utilized to manage changes in the skin itself, such as fine wrinkles and loss of elasticity.
Both treatments can be considered for improving skin texture and fine wrinkles, but the principles of action on the skin are different. Therefore, in cases where there is excessive sebum production leading to prominent pores and cases where fine wrinkles increase due to loss of skin elasticity, the choice of treatment and application methods may vary.
Which Skin Concerns May Skin Botox Help Address?
Skin Botox is a treatment that involves the dispersed injection of small amounts of botulinum toxin into relatively shallow layers of the skin. While regular Botox is used to control the contraction of specific facial muscles, Skin Botox focuses on subtle changes that appear on the skin surface.
Botulinum toxin is a substance that inhibits the secretion of the neurotransmitter acetylcholine. The method of injecting it into the shallow layers of the skin has been researched for its purpose of managing sebum production, skin texture, and fine wrinkles.
For example, if there is excessive sebum production causing prominent pores around the nose or cheeks, a reduction in sebum production can be expected to improve the appearance of the pores. However, it does not permanently reduce the structure of the pores, and the effectiveness may vary depending on the causes of the enlarged pores.
It is also used to improve fine wrinkles and skin texture that appear on the skin surface. It can be considered especially when there are concerns about shallow wrinkles and subtle changes on the skin surface, but it does not uniformly improve deeply entrenched wrinkles or severe loss of elasticity.
Additionally, Skin Botox works differently from treatments that directly supply moisture to the skin. If the skin is dry and fine wrinkles are prominent, the moisture level, skin barrier, and loss of elasticity should also be considered.
Potential benefits of Skin Botox for skin texture and pore appearance have been observed in clinical studies, but results may vary depending on the application area and injection method, and further research is needed in this area.
How does Rejuran work on the skin?
Rejuran is an injection treatment that primarily consists of PN (Polynucleotide). PN is a refined component derived from salmon DNA fragments, which has the characteristic of supporting the recovery and regeneration environment of skin tissue.
Rejuran is utilized to deliver PN components to the dermis layer of the skin to improve the condition of skin tissue. Due to this characteristic, it can be considered when there are concerns about fine wrinkles, loss of elasticity, and rough skin texture.
For example, if the skin on the cheeks becomes thinner and loses elasticity, leading to an increase in fine wrinkles, an approach that improves the condition of the skin tissue, rather than just making the skin surface appear smooth, may be necessary.
Rejuran differs from Skin Botox in that it utilizes PN components for these skin changes.
Additionally, changes in skin condition do not all appear immediately after the treatment but can be observed over a certain period. Clinical studies using PN also evaluate changes in fine wrinkles, skin texture, and elasticity over multiple sessions.
However, Rejuran does not yield the same results for all skin concerns. In cases of excessive sebum production leading to prominent pores and those centered on loss of skin elasticity, the expected range of improvement may differ.
When Can Changes Be Observed After Skin Botox and Rejuran?
Since Skin Botox and Rejuran have different ingredients and mechanisms of action, there may also be differences in the timing of observing changes in the skin.
Skin Botox is a treatment that utilizes the action of botulinum toxin, and the effects are not completed immediately after injection. Over time, the action of the ingredients becomes apparent, and changes in sebum production, skin texture, and fine wrinkles may be observed differently depending on the application area and treatment method.
The action of botulinum toxin is temporary, so the effects gradually diminish over time. The actual duration of effects is influenced by the product used, the amount injected, skin condition, and individual responses.
In contrast, Rejuran is a treatment that improves the condition of skin tissue through PN components, evaluating changes over a certain period after the treatment. Fine wrinkles, elasticity, and skin texture may show gradual changes depending on multiple sessions and subsequent progress.
Additionally, both treatments may cause temporary redness, swelling, and injection marks immediately after injection. These reactions are distinct from actual improvement effects, and the recovery speed may vary among individuals.
Skin Botox evaluates changes based on the action of botulinum toxin, while Rejuran focuses on changes in skin condition after PN injection. Therefore, rather than simply comparing the results of both treatments at the same time point, the progress is observed based on the characteristics and improvement goals of each treatment.
Can Skin Botox and Rejuran be performed together?
Skin Botox and Rejuran have different mechanisms of action, so depending on the skin condition, you may consider applying them separately or in combination.
For example, if there is excessive sebum production causing prominent pores around the cheeks while skin elasticity decreases and fine wrinkles increase, you can consider managing sebum and pores as well as improving the condition and elasticity of the skin, which are different objectives.
Skin Botox can be applied to manage sebum production and changes on the skin surface using botulinum toxin, while Rejuran can be utilized to aid in the recovery and improvement of skin condition through PN components.
However, applying both treatments together does not necessarily mean that each effect will be magnified. Depending on the actual skin condition, it may be possible to achieve improvement goals with just one treatment, and when different concerns appear together, the roles of each can be distinguished for consideration of combination.
When applying both treatments to the same area, factors such as product characteristics, injection depth, dosage, and skin reactions must be considered. Whether to perform the treatments simultaneously or with a certain interval may also vary depending on skin condition and recovery process.
How Does AMRED Choose Between Skin Botox and Rejuran?
AMRED examines changes in both the skin surface and the condition of skin tissue in Skin Botox and Rejuran treatments, planning the treatment based on the areas that need improvement.
For example, if there is excessive sebum production causing prominent pores around the nose and cheeks, the shape of the pores and the condition of the surrounding skin can be assessed to consider the application of Skin Botox.
On the other hand, if the elasticity of the skin on the cheeks decreases, leading to an increase in fine wrinkles or rough skin texture, the thickness and elasticity of the skin can be considered to assess the need for Rejuran application.
Especially when both pores and fine wrinkles appear, it is important to distinguish whether the changes are due to sebum production or influenced by loss of skin elasticity to determine the scope and method of treatment.
AMRED utilizes a 4D aging-analysis framework as a basis for treatment design to examine these skin changes. It considers detailed changes (DETAIL) such as pores, fine wrinkles, and skin texture, as well as the density and elasticity of the skin and tissue (DENSITY), overall facial balance (DESIGN), and changes and maintenance over time (DURABILITY).
Based on this, areas needing skin surface management using botulinum toxin and areas needing improvement in skin condition using PN components are distinguished, and the types of treatments and application scopes are planned according to individual skin conditions.
Even for the same concerns about fine wrinkles and skin texture, the causes and conditions of the skin tissue may differ. AMRED selects necessary treatments based on these differences and applies them considering the overall balance of the skin.
4D is a proprietary aging analysis and treatment design perspective defined by AMRED, and does not refer to an independent medical diagnostic classification or a single treatment name.
Actual treatment plans may vary based on the medical staff's examination and individual conditions.
AMRED is a premium private skin clinic in Cheongdam, Seoul. We offer English-language support for consultations, appointments and post-treatment care guidance. Share your skin concerns and travel dates with us, and our team will help you arrange your consultation and visit.
For booking inquiries, please contact us on WhatsApp.